[이정헌, 최재영 교수님_Nanoletters] Single-Chain Atomic Crystals as Extracellul…
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□ 게재 학술지명: Nano Letters
□ 주저자: 이 정 헌, 최 재 영
□ IF : 12.080
□ 논문소개
본 연구에서는 약0.6nm의 하나의 직경을 갖으며, 큰 표면적 및 기계적으로 유연한 특성을 갖는 Mo3Se3 (단일 사슬 원자 결정)을 합성하여 조직 공학 응용을 위한 비계 재료를 모방 한 세포 외 기질 (ECM)로의 적용을 연구하였다. Mo3Se3-SCACs와 함께 48 시간 배양된 L-929 및 MC3T3-E1의 세포 증식은 각각 268.4 ± 24.4 % 및 396.2 ± 8.1 % 로 증가했다. 세포가 200 μg mL-1의 Mo3Se3-SCACs로 처리 되었을 때 매우 높은 증식이 관찰되었으며 이는 이전에 보고 된 대부분의 나노 물질들이 가지고 있는 세포 독성의 농도 대비 높은 생존력을 보이고 있습니다. 유리 기판 상에 Mo3Se3-SCACs를 코팅함으로써 제조 된 세포외 기질 – 모방 scaffold 필름은 세포 접착의 초기 단계에서 세포가 표면에 부착 될 수 있게 한다. 세포 외 기질 – 모방 scaffold 필름상에서 배양 된 대부분의 세포는 살아남았고; 대조적으로, Mo3Se3-SCAC 코팅 없이 유리 기판 상에 배양 된 상당한 수의 세포는 생존하지 못했다.
즉, 이 연구는 Mo3Se3-SCAC의 뛰어난 생체 적합성 및 생체 활성 특성을 증명 할뿐만 아니라 세포 외 기질 – 모방 scaffold 필름 발판 물질로서 Mo3Se3-SCACs 는 대부분의 다른 나노 물질의 몇 가지 중요한 한계를 극복 할 수 있었다.
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